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| Cat. Number | 10-4511 |
| Chemical Name | βR-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile |
| CAS Number | 941678-49-5 |
| Mol. Formula | C17H18N6 |
| Mol. Weight | 306.37 |
| Qty 1 |
5mg |
| Qty 2 | 25mg |
| Appearance | White solid |
| Application Notes | 99% by HPLC NMR (Conforms) |
| Synonym | INCB 018424 |
| Solubility | Soluble in DMSO (up to 28 mg/ml) or in Ethanol (up to 15 mg/ml with warming). |
| Storage condition | -20℃ |
| Stability | Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| References |
Potent and selective JAK1&2 inhibitor, IC50s=2.7, 4.5 and 322 nM forJAK1, JAK2 and JAK3 respectively.1 Blocks IL-6 signaling (IC50=281 nM) and proliferation of JAK2V617F+ Ba/F3 cells (IC50=127 nM).2 Inhibits the proinflammatory secretome of senescent cells.3 The JAK1 S646P mutant is highly sensitive to ruxolitinib.4 Clinically useful cancer chemotherapeutic.
References/Citations
Ruxolitinib ，货号10-4511 上海惠诚提供5mg 25mg Ruxolitinib，美国focus原装进口，咨询电话021-60498804
Ruxolitinib ，货号10-4511 上海惠诚提供5mg 25mg Ruxolitinib，美国focus原装进口，咨询电话021-60498804
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