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Cat. Number
10-2686
Chemical Name
3-Methyl-3H-purin-6-amine
CAS Number
5142-23-4
Mol. Formula
C6H7N5
Mol. Weight
149.15
Qty 1
20mg
Qty 2
100mg
Appearance
White solid
Application Notes
98% by TLC NMR (Conforms)
Synonym
3-MA
Solubility
Soluble in DMSO (up to 3 mg/ml), or in DMF (up to 10 mg/ml).
Storage condition
-20℃
Stability
Stable for 2 years as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.
References

3-Methyladenine (5142-23-4) inhibits autophagy by blocking autophagosome formation via inhibition of type III phosphatidylinositol 3-kinases (PI-3K)1,2. Protects 1321N1 astrocytoma cells against pyocyanin and hydroxyphenazine-induced toxicity3. 3-Methyladenine enhances induction of apoptosis by celastrol (Cat.# 10-2187) in human pancreatic cancer cells4.

References/Citations
1) Seglen and Gordon et al. (1982), 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes; Proc. Natl. Acad. Sci. USA, 79 1889
2) Blommaart et al. (1997), The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes; Eur. J. Biochem., 243 240
3) McFarland et al. (2012), Inhibition of autophagy by 3-methyladenine protects 1321N1 astrocytoma cells against pyocyanin- and 1-hydroxyphenazine-induced toxicity; Arch. Toxicol., 86275
4) Zhao et al. (2014), Inhibition of autophagy strengthens celastrol-induced apoptosis in human pancreatic cancer in vitro and in vivo models; Curr. Mol. Med., 14 555

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3-甲基腺嘌呤 英文名称3-Methyladenine ,货号10-2686 上海惠诚提供100mg 50mg 3-甲基腺嘌呤 3-Methyladenine,美国focus原装进口,咨询电话021-60498804

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