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Cat. Number
10-2412
Chemical Name
5-Aza-2'-deoxycytidine
CAS Number
2353-33-5
Mol. Formula
C8H12N4O4
Mol. Weight
228.21
Qty 1
10mg
Qty 2
50mg
Appearance
White solid
Application Notes
98% by TLC NMR (Conforms)
Synonym
NSC-127716
Solubility
Soluble in DMSO (up to 25 mg/ml) or in Water (up to 11 mg/ml).
Storage condition
-20℃
Stability
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
References

Decitabine (2353-33-5) inhibits DNA methyltransferase. Induces demethylation and reactivation of silenced genes. Increases stem cell reprogramming efficiency. Decitabine stimulates osteogenic differentiation of human bone marrow stromal cells. Antitumor agent. Cell permeable.

References/Citations
1) Bender et al. (1998), Inhibition of DNA methylation by 5-aza-2'-deoxycytidine suppresses the growth of human tumor cell lines; Cancer Res., 58 95
2) El-Serafi et al. (2011), Epigenetic modifiers influence lineage commitment of human bone marrow stromal cells: Differential effects of 5-aza-deoxycytidine and trichostatin A; Differentiation, 81 35

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