(9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid_上海惠诚生物科技有限公司试剂,标准品,蛋白

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Cat. Number	10-2187
Chemical Name	(9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
CAS Number	34157-83-0
Mol. Formula	C29H38O4
Mol. Weight	450.62
Qty 1	5mg
Qty 2	25mg
Appearance	Red Solid
Application Notes	98% by TLC NMR (Conforms)
Synonym	(9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
Solubility	Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 30 mg/ml).
Storage condition	-20℃
Stability	Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
References	Celastrol (34157-83-0) displays potent antioxidant and anti-inflammatory activity. Inhibits NFkB (IC50=270 nM). It induces heat shock response and cytoprotection in various cells. Inhibits 20S proteasome chymotrypsin activity (IC50=2.5 mM). Induces autophagy by targeting AR/miR-101 in prostate cancer cells.4 Induces UPR-dependent cell death in cancer cells.5 Cell permeable. References/Citations 1) Sethi et al. (2007), Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κC-regulated gene products and TAK1-mediated NF-κB activation; Blood, 109 2727 2) Westerheide et al. (2004), Celastrols as inducers of the heat shock response and cytoprotection; J. Biol. Chem., 279 56053 3) Yang et al. (2006), Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine" is a potent proteasome inhibitor and suppresses human prostate cancer cell growth in nude mice; Cancer Res., 66 4758 4) Guo et al. (2015), Celastrol Induces Autophagy by targeting AR/miR-101 in Prostate Cancer Cells; PLoS One, 10(10) e0140745 5) Fribley et al. (2015), Celastrol induces unfolded protein response-dependent cell death in head and neck cancer; Exp. Cell Res., 330 412 雷公藤红素英文名称Celastrol，货号10-2187上海惠诚提供5mg 25mg雷公藤红素 Celastrol，美国focus原装进口，咨询电话021-60498804
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