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Cat. Number
10-2179
Chemical Name
1,4-Diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene
CAS Number
109511-58-2
Mol. Formula
C18H16N6S2
Mol. Weight
380.49
Qty 1
5mg
Qty 2
25mg
Appearance
White solid
Application Notes
99% by TLC and HPLC
Synonym
1,4-Diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene
Solubility
Soluble in DMSO (up to 200 mg/ml).
Storage condition
-20℃
Stability
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
References

U0126 (109511-58-2) is a highly selective inhibitor of MEK1 and MEK2 in vitro and in vivo. Unlike PD98059 (Cat.# 10-2159), which only inhibits the activation of MEK1 and MEK2, U0126 inhibits both the active and inactive forms of the MEK enzymes. Inhibition of MEK1 and MEK2 has been demonstrated to enhance the self renewal of stem cells.

References/Citations
1) Favata et al. (1998), Identification of a novel inhibitor of mitogen activated protein kinase kinase; J. Biol. Chem., 273 8623
2) Miyoshi et al. (2012), Antitumor activity of MEK and PI3K inhibitors against malignant pleural mesothelioma cells in vitro and in vivo; Int. J. Oncol., 41 449
3) Pricola et al. (2009), Interleukin-6 Maintains Bone Marrow-Derived Mesenchymal Stem Cell Stemness by an ERK1/2-Dependent Mechanism; J. Cell Biochem., 108 577

Focus Biomolecules supplier, chemical structure of U0126 | Selective MEK1 and MEK2 inhibitor | CAS 109511-58-2

U0126,货号10-1011 上海惠诚提供5mg 25mg U0126,美国focus原装进口,咨询电话021-60498804

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