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Cat. Number	10-2177
Chemical Name	托法替尼 Tofacitinib
CAS Number	477600-75-2
Mol. Formula	C16H20N6O
Mol. Weight	312.37
Qty 1	5mg
Qty 2	25mg
Appearance	Off-white solid
Application Notes	99% by HPLC and TLC NMR (Conforms)
Synonym	Tasocitinib, CP-690550
Solubility	Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 100 mg/ml).
Storage condition	-20℃
Stability	Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
References	Tofacitinib (477600-75-2) is a potent pan-JAK inhibitor, IC50s=1, 20 and 112 nM for JAK3, JAK2 and JAK1 respectively.1 Displays potent antiinflammatory2 and immunosuppressant3 activity. Promotes a white-to-brown metabolic conversion in human adipoctes.4 In therapeutic use for rheumatoid arthritis.5 . References/Citations 1) Jiang et al. (2008), Examining the chirality, confirmation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitril (CP-690,550); J. Mol. Chem., 51 8012 2) Cutolo and Meroni (2013), Clinical utility of the oral JAK inhibitor tofacitinib in the treatment of rheumatoid arthritis; J. Inflamm. Res., 6 129 3) Martina et al. (2016), Inhiition of JAK3 and PKC via Immunosuppressive Drugs Tofacitinib and Sotrastaurin Inhibits Proliferation of Human B Lymphocytes In Vitro; Transplant. Proc., 48 3046 4) Moisan et al. (2015), White-to-brown metabolic conversion of human adipocytes by JAK inhibition; Nat. Cell Biol., 17 57 5) Dowty et al. (2014), Preclinical to clinical translation of tofacitinib, a Janus kinase inhibitor, in rheumatoid arthritis; J. Pharmacol. Exp. Ther., 348 165 托法替尼英文名称Tofacitinib ，货号10-2177 上海惠诚提供5mg 25mg 托法替尼 Tofacitinib，美国focus原装进口，咨询电话021-60498804 托法替尼英文名称Tofacitinib ，货号10-2177 上海惠诚提供5mg 25mg 托法替尼 Tofacitinib，美国focus原装进口，咨询电话021-60498804
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