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| Cat. Number | XAV939 |
| Chemical Name | XAV939 |
| CAS Number | 284028-89-3 |
| Mol. Formula | C14H11F3N2OS |
| Mol. Weight | 312.31 |
| Application Notes | >99 % |
| Solubility | Soluble to 50 mM in DMSO |
| Storage condition | Store at RT |
| References | Tankyrase (TNKS) inhibitor (IC50 values are 0.011 and 0.004 μM for TNKS1 and TNKS2 respectively). Antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. Inhibits proliferation of the beta-catenin-dependent colon carcinoma cell line DLD-1 1.
Product Specification M.Wt: 312.31 Formula: C14H11F3N2OS Solubility: Soluble to 50 mM in DMSO Purity: >99 % Storage: Store at RT CAS No: [284028-89-3]
1. Huang, S.A., Mishina, Y.M., Liu, S., et al. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature 461 614-619 (2009). |
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