Room temperature
in continental US; may vary elsewhere
SMILES
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OC(=O)CSc1nc(cc(Cl)n1)Nc1cccc(C)c1C
Background Reading
Devchand, P.R., Keller, H., Peters, J.M., et al. The PPARα-leukotriene B4 pathway to inflammation control. Nature38439-43(1996).
Lehmann, J.M., Lenhard, J.M., Oliver, B.B., et al. Peroxisome proliferator-activated receptors a and g are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem2723406-3410(1997).
Keller, H., Devchand, P.R., Perroud, M., et al. PPARα structure-function relationships derived from species-specific differences in responsiveness to hypolipidemic agents. Biol Chem378651-655(1997).
Schmidt, A., Endo, N., Rutledge, S.J., et al. Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids. Mol Endocrinol61634-1641(1992).
Staels, B., Koenig, W., Habib, A., et al. Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators. Nature393790-793(1998).
Hsu, M., Palmer, C.N.A., Griffin, K.J., et al. A single amino acid change in the mouse peroxisome proliferator-activated receptor α alters transcriptional responses to peroxisome proliferators. Mol Pharmacol48559-567(1995).
Wy 14643 is a peroxisome proliferator-activated receptor (PPAR activator). Although this compound is primarily an activator of PPARα,1,2,3 it activates PPARγ as well.4 Activation of PPARδ by Wy 14643 is also observed,5 but this finding is rare. The potency of Wy 14643 as an activator of PPARα is species dependent, with receptor activation occurring at concentrations as low as 0.1 µM in the mouse compared to 10 µM in Xenopus.6
1
Devchand, P.R., Keller, H., Peters, J.M., et al. The PPARα-leukotriene B4 pathway to inflammation control. Nature38439-43(1996).
2
Hsu, M., Palmer, C.N.A., Griffin, K.J., et al. A single amino acid change in the mouse peroxisome proliferator-activated receptor α alters transcriptional responses to peroxisome proliferators. Mol Pharmacol48559-567(1995).
3
Staels, B., Koenig, W., Habib, A., et al. Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators. Nature393790-793(1998).
4
Lehmann, J.M., Lenhard, J.M., Oliver, B.B., et al. Peroxisome proliferator-activated receptors a and g are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem2723406-3410(1997).
5
Schmidt, A., Endo, N., Rutledge, S.J., et al. Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids. Mol Endocrinol61634-1641(1992).
6
Keller, H., Devchand, P.R., Perroud, M., et al. PPARα structure-function relationships derived from species-specific differences in responsiveness to hypolipidemic agents. Biol Chem378651-655(1997).
